Showing posts with label chemists corner. Show all posts
Showing posts with label chemists corner. Show all posts

Monday, February 28, 2022

MAGIC MUSHROOMS GONNA BE APPROVED FOR GENERAL POPULATION SOON

 AND I QUOTE: "Oral psilocybin is showing itself to be clinically efficacious by producing statistically significant reductions in depression and anxiety symptoms over time versus control in multiple clinical trials. It has also been shown to reduce cigarettes per day and drinks per day in patients with substance use disorders. Thus far, there have been no significant adverse clinical events from psilocybin and there also have been no verifiable recorded deaths reported. Larger studies need to be performed before the drug can potentially become approved for use in the general population."

Hodge AT, Sukpraprut-Braaten S, Narlesky M, Strayhan RC. The Use of Psilocybin in the Treatment of Psychiatric Disorders with Attention to Relative Safety Profile: A Systematic Review. J Psychoactive Drugs. 2022 Feb 28:1-11. doi: 10.1080/02791072.2022.2044096. Epub ahead of print. PMID: 35225726.

Thursday, May 21, 2020

perfume ingredients for detergent soap

ok
check this out
ever heard of client from hell a design team in toronto ? i bike by their office sometimes
 anyway i was just going on an algorhythm tip no doubt and found this
ok
so im looking up aromatic chemicals and one of the ones presented to me, not something i searched literally was geranyl nitrile and i found on the good scents company the ifra is prohibiting this ingredient for perfume use but its being sold as a perfume ingredient. its been used on rats and rabbits when they force the animals large doses of this material until they die. so they know how toxic this ingredient is. yikes. this is the prohibiting body. so it looks like this patent for a plastic end piece for a tube packaged laundry detergent went through some revisions. perfume revisions. im not sure but have a look, its lol. client from hell you say? how bout perfume reformulations for plastic packaging specifications? axe body spray allergies causing anaphylactic shock and cant reveal formula you say?
https://patents.google.com/patent/US4741856
 just for example. the material geranyl nitrile is a potential aquatic life disruptor according to the prohibiting body that tests on rats and rabbits (did they do a long term aquatic study ? i thought it sounds like its from geranium)  and according to this google patent is been used in laundry detergent since 1987...i think ... mass produced cos who has the money to patent the development of the plastic end tube packaging? wonder what laundry detergent this is? i will research the material now cos its kind of weird. im not sure what to use. obviously i wont use the rat and rabbit tested stuff if i find out. gee. let me check now. cant they test somehow in another way? i guess not. they do weird tests on humans enough as it is... oh so much to do!
the amount of scent you need to make something smell good when you whiff it from the bottle is how consumers buy things and that amount is HUGE and actually if you dilute it.... like hey ever buy a huge bottle of dish soap that your crazy bf uses up in two days ? but actually what you learned to do is dilute like a teaspoon in 2 cups of distilled water and use it for a week? i mean, wow lets just perfume the world via our kitchen and laundry sinks, only thing perfume making doesnt work that well this way. ive made so many weird combinations to know.

wow ok so this patent i found off the good scents database,
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4,330,417.PN.&OS=PN/4,330,417&RS=PN/4,330,417 
is from 1928 the original laundry detergent and fabric softner, a fresh lemony aroma, apparently, or perfume. about .20% of the patent ingredient is used and the formula uses .10 in 1300 or something, geranyl nitrile has been used as a perfume ingredient for various household and personal products since 1928 and all the info theye could find was torturing rabbits and rats? consumer privacy and research and unknown cumulative toxicitiy there must be an easier way. i mistyped mist and imagine if the corona virus was actually some kind of mist or particle from some form of banned ingredient found out by the perfume industry. like some of these ingredients arent actually perfume ingredients, they just have a nice smell so the perfume industry has access to them. yikes. to know is half the battle but what if its just too long and what is a timeline anymore? maddening.

ok wtf
i just found this ban on the substance as a perfume ingredient for detergent
https://ifrafragrance.org/standards/IFRA_STD48_0053.pdf
 from 2009

is this a nitrile form from geranium>????? i dont understand how this ingredient was made. why do they use geranyl as a name ? there are many geranyl ingredients that are natural isolates that are not toxic?
like as in cyanide? like nitriles are like glues, so if its a bastard of geranium that sticks around too long, it was part of a lemony aroma that lasted in laundry soap so its not necessarily lemony and if its for a freshness it sounds like geranium doesnt it. please dont make me be the one to look this shit up i just wanted to make perfume and actually yes i realize i cant sell any of the perfumes now without looking up the ingredients to some degree, specially not blends from other companies who cannot disclose their perfume ingredients? like really my day is spent stressing on where to throw the trash vs recylcing and knowing and not doing due to other things like doing this? wth?
or wth am i actually reading ugh
ok so its banned since 2009 for found toxicity to aquatic life found out from testing on animals
its been used as a laundry detergent perfume ingredient since 1980
its still being sold today
good thing i didnt buy it!! or did i??
is this ingredient used in any of the essential oil perfume blends i buy as perfume ingredients? if its a compound from a natural ingredient forced into a specific shape for its prolonged odor for rinse off products is this in the woolzies stuff that use for dryer balls ? is it considered a distillate? ugh im the rat now. honestly i feel tortured... avatars from basenotes haunt me like ebeneezer scroodge and the fairys and godmothers of tales you wished were true before you read other things not meant for children.... hand me that baby product............200 years later mutant humans with scratch and sniff areas of the body that detect diseases in their dna matches world wide but are only found under specific constraints and the battle for privacy reigns supreme!! natural deaths for the anarchists!! vegan terrorists corona virus rabbit testing isis flag plant double take in a british gay rally using shame to shun a female reporter https://www.dailymail.co.uk/news/article-3142221/CNN-confuses-black-white-flag-covered-sex-toy-symbols-ISIS-London-gay-pride-parade.html what the actual fuuuck ?????? anyway just something to think about. i have to dig for that not actually an isis gay flag link now and link the shame post https://en.wikipedia.org/wiki/So_You%27ve_Been_Publicly_Shamed but holy hell man....

i mean wow this is just a few hours of chillin on my own using the internet and my mind, i wish i was housed like i have to go through the ads and bike around and im just so tired of traps and such. its hard gains when youre noticing specific perfume ingredients. i mean my mind is so blown and my shade spot is sunny so i have to go, before i you know, get cancer and mutate!!!!!ok i checked. its not getting cancer and mutating. its not carcinogenic to humans, its toxic to fresh water fish, like this delicious lookin bugger, lauscisus isus...say that again?
https://en.wikipedia.org/wiki/Ide_%28fish%29

so its a no for laundry. lethal concentration for 50% of the animals, in this case this cute fresh water fish native to europe and asia waterways according to wikipedia, is LC50 - Leuciscus idus (Golden orfe) - > 22 - 44 mg/l - 96 h (msds found here http://finoric.com/Aromatics/Geranylnitrile.htm) so that means the fish die? in 1-96 hours of 22-44 mg in what? in the lake? you use .01% in the total fragrance concentration or less than that for the total but if its millions of people  (or even say 50,000 people using this laundry detergent for 40 years in one area) using it and all the washing machine run off goes through one area which seeps into the fresh water way a few kilometers over by underground passages and then these fish all die. wtf? cos this damn geranyl nitrile? damn! how did the fish die .... is the new why did the chicken cross the road?

omg i just should stop checking the new links as i go along

now i find ok supply chains. so this one supplier i find in the u.s. gets chems from india and china and this one indian patent is getting geranyl nitrile from essential oil https://www.allindianpatents.com/patents/195658-a-process-for-the-prepration-of-geranyl-nitrile-from-lemon-grass-oil  let me just keep reading this and ... does anyone want to get me lunch? i missed lunch again. ugh.
ok so it says here
"However isolation of citral from natural source such as essential oil of lemon grass may either be achieved by fractional distillation of the oil or by derivatisation such as bisulfite formation which is followed by liberation of citral by treatment with alkali solution. Lemon grass oil (Cymbopogon pendulus fam. Grahminae) contain almost 65-70% of citral which is a mixture of two stereoisomers, viz. citral a (65%) and citral b (35%) (Sharma, J.R., Lai, R.K. Mishra, H.O. and Naqvi, A., current science 197, 56, 30; and Patra, P and Dutta, P.K. Res. & Ind. 1986, 31, 358). "

so basically you can get geranyl nitrile from a natural source and it could be called a distillate of an essential oil of lemongrass, but this isolate is a known irritant to freshwater fish and soil pollutant which would seep into fish. its got a lemony fresh odor, its similar to lemonile in name/term (which i have but havent used cos its so strong and theres a note of metal in it that i find offensive to my nose even at the smallest concentration- i was nudged by pk paulkiler in basenotes to check it out at a low concentration, even in traces, so i havent tried it in formula in trace yet, but im smelling the dilution that i would use to be able to use it in trace and i already find it offensive like you somehow smell metal on your skin and you think of tetanus)

ok so now what? one ingredient ill remember not to try to use based on the ifra ban which ill trust because i havent found the fish study. and i need to go outside and ship some items. and eat something. maybe ill have some fish. i dont know anymore.....

Saturday, February 09, 2019

amber perfume

damn it to hell my lotion smells like dill and cucumbers, a sea of cucumbers by bath and body works is what my friend said and i wanted to throw it away. whatever. he was using axe products when i met him. anyway i made a simple fresh amber perfume and got to smell it again today, thank god i wrote the formula down because i love it and want to repeat it. though, without the lavender alcohol i made it might not smell the same. so there are variations.
it smells of vanilla, sandalwood, musk, lavender extract, and heliotrope. the lavender alcohol i made, its green, and it smells of hay and dried grass and lavender. the amber perfume is very nice and mild and natural smelling even though its mostly aroma chems in the lavender alcohol as a base.  still going to make an amber using essential oils only. labdanum, im almost out and want to try it from a different supplier to get a better sense of it. and vetiver, sandalwood and benzoin. im dreaming of it because i made something similar and the smell was amazing resinous and balsamic but im not sure if i have a good handle on what balsamic smells like. or resinous for that matter. the vetiver from botanic planet is so good it smells like a perfume on its own. just amazing. and the magnolia leaf in low dilution was like how farnesol smells in trace. i made a .01 in 10 grams and it smells similar to isobutavan, to me, it has a vanilla cream aspect to it. im not sure though since i only have so few chemicals to smell. mostly im super impressed with learning the ratios of using the essentials oils when i look up demo formulas in the good scents company, like this recent chypre i copied. ive been using these oils for years now but never figured out the concentrations for example petitgrain, i would never use it higher than other oils or corriander seed which i recently bought but havent used much due to its strength, i wouldnt pair it at the same ratio of anything but in the chypre formula i copied from good scents the ratios of these strong materials is very high, same with the galbanum, such a strong material, but the smell is great in this formula, i can tell how much i over dosed based on the formula (tweaked the ratios as well as made lots of substitution) and im just really glad i found this new hobby to learn how to use the essential oils as perfume. most of the perfumes im making could be all essential oils if i could afford them because these chemicals are really strange, for example farnesol has a anti fugal activity ? or is it anti bacterial, on a certain organism. on human skin. i do not remember the concentration because i dont think i read the entire study, but i do remember the sandalore concentration and its something like .005 lol. really miniscule. that was the concentration in the cream preparation or what did they use to apply it, on the skin, for the sensors to sense the chemical in its atmosphere to stimulate a growth stage of hairs. they dissected mice for this. there are close up pictures of the mice hairs sliced ala damien hurst, growing. pretty intense. im not sure if the study detailed humans? now that im recalling the horror of reading this study just to prove science, im getting rather ill and wonder if it was actually the sandalore study. oh man to be a mouse in a little test zone...oh wait. .
so i was going to rereate the amber perfume but i should buy pipettes. the tiny sample bottles are wasted with little drips around the rims when i use a toothpick to guide the drops, so inaccurate as well. all my formulas since i stopped reusing droppers have been pure luck or misfortune, for example the galbanum overdose. ugh. . .
because i wonder what the smoking violets perfume would smell like with an amber base. havent even finished my design for the label.  did housekeeping today and have some money to buy supplies even though i shouldnt because its not what i should be doing. woops. so greedy vs reality. but single use droppers are absolutely essential ever since my black agar and smelled like it had cassis. ugh.. also found a low cost .001 scale with the auto shut off feature shut offable.
ahh im just touching my hands that were over dry but now totally smoothed over from using the lotion. an amber lotion would be choice! now that i know how to make a fluffy and creamy lotion, this is the formula i wanted for the smoking violets lotion. just hadnt made it yet, and still havent because i made the formula in my head as it was coming along and it was over 100% hmmm also the lotion has some ethanol in it and i could feel it on my over dry skin the first time i put it on, it was like yeow, same thing when i put it on my face, around my nose, it stung yikes, but wow on my hands it was super stingy but worth it i guess because my hands cured super fast and the skin smoothed over. and it doesnt sting when i use it anymore. there was broken / dry skin so it stung. much like when i used the lavender alcohol diluted on over dry plus lye fume burned hands. for the lotion i used .10 of sodium lactate and 2% ipm and 2% dimethicone as recommended in swifts lotions, 78% water so its really fluffy with mostly peach kernel oil. ahhh im so pleased and want that amber lotion! im lucky to have these comforts. oh yeah actually i fudged when my bank was locked i was in the middle of supply shopping and actually i had some preservatives in a bought cart i couldnt pay for. my preservative is all clumpy and done. i should have added it to glycerine or something, i have some in peg 400 but no one uses that stuff topically. and i have the phenoxyethanol and caprylyl glycol stuff but its not antifungal. sighing til diy'ing. oh yeah and i forgot about my new use for xylitol. hey wheres my lame go fund me <<<<< insert link hither

Wednesday, January 09, 2019

cosmetology and aromatherapy school of hard knocks

ahh it feels like im in grade school
paying my lunch dollar to susan and listening to perry on youtube
meanwhile my case studies are totally pending and giving me writers block
because i was up all night reading about other things i dont need to write reports on